Nutrient Therapy Biochemical Research

This is a list of some of the research I have come across in my own search for published scientific literature on the subject while writing my articles. It is by no means exhaustive of what is available out there, especially as far as the earlier decades and the general literature concerning the effects of nutrient deficiencies are concerned.

Hoffer/Pauling/Pfeiffer publications:

Orthomolecular Psychiatry: Varying the Concentrations of Substances Normally Present in the Human Body May Control Mental Disease http://vrfca.org/wp-content/uploads/2012/08/Linus-Pauling-1968.pdf

The Association Between Schizophrenia and Two Objective Tests https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849595/

Hydroxy-Hemopyrrolenone, not Kryptopyrrole, in the Urine of Schizophrenics and Porphyrics http://www.clinchem.org/content/24/11/2069.full.pdf

COMBINED ZINC AND VITAMIN B6 DEFICIENCY IN PYROLURIA: A TYPE OF SCHIZOPHRENIA https://www.researchgate.net/publication/301032852_COMBINED_ZINC_AND_VITAMIN_B6_DEFICIENCY_IN_PYROLURIA_A_TYPE_OF_SCHIZOPHRENIA

Treatment of Pyroluric Schizophrenia (Malvaria) With Large Doses of Pyridoxine and a Dietary Supplement of Zinc http://orthomolecular.org/library/jom/1974/pdf/1974-v03n04-p292.pdf

Walsh publications:

The Effectiveness of Targeted Nutrient Therapy in Treatment of Mental Illness http://www.aph.gov.au/Parliamentary_Business/Committees/House_of_representatives_Committees?url=ee/mentalhealth/subs/attach01.pdf

Elevated serum copper levels in women with a history of post-partum depression http://www.biobalance.org.au/_downloads/journal-of-trace-elements-in-medicine-and-biology.pdf

Elevated Blood Copper/Zinc Ratios in Assaultative Young Males https://www.walshinstitute.org/uploads/1/7/9/9/17997321/elevated__blood_cu_and_zn_ratios__in_assaultive_young_males.pdf

Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial http://online.liebertpub.com/doi/full/10.1089/cap.2016.0199

Reduced Violent Behaviour Following Nutrient Therapy http://www.hriptc.org/pdfs/Behavior%20paper%20-%20Elsiver%20-%20final%202.pdf

Discerning the Mauve Factor

HPL (“pyrroles”) as a good marker for diagnosis.

Full Walsh Research Institute publications on their website, including Powerpoint presentations and conference papers https://www.walshinstitute.org/researchstudies.html

Other related publications:

Clinical Test of Pyrroles: Usefulness and Association with Other Biochemical Markers https://riordanclinic.org/wp-content/uploads/2015/04/CMRCR-2-027-Pyrroles.pdf

Overview of Urinary Pyrrole/Mauve Factor Analysis https://www.truevitality.com.au/articles/pyroluria/

General Deakin University study in nutrition and depression http://www.deakin.edu.au/about-deakin/media-releases/articles/world-first-trial-shows-improving-diet-can-treat-major-depression

Prof Julia Rucklidge Research publications

Vitamin-mineral treatment improves aggression and emotional regulation in children with ADHD: a fully blinded, randomized, placebo-controlled trial http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12817/abstract

Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomised placebo-controlled trial http://bjp.rcpsych.org/content/204/4/306.full

Nutritional therapies for mental disorders https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-7-2

Nutrition and Mental Health http://journals.sagepub.com/doi/10.1177/2167702616641050

What if nutrients could treat mental illness? http://journals.sagepub.com/doi/10.1177/0004867414565482

Effect of Micronutrients on Insomnia in Adults http://journals.sagepub.com/doi/10.1177/2167702616631740

Full Rucklidge research publications on ResearchGate (free access) https://www.researchgate.net/profile/Julia_Rucklidge/contributions

General nutrient research representative studies

Zinc deficiencies implicated in Autism onset https://medicalxpress.com/news/2018-11-autism-zinc-deficiency-early-developmentnow.html

Effects of Zinc Supplementation in Patients with Major Depression: A Randomized Clinical Trial http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796297/

Decreased Zinc and Increased Copper in Individuals with Anxiety http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738454/

Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala http://ajcn.nutrition.org/content/92/5/1241.short

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